ARSA c.465+1G>A

ARSA c.465+1G>A

The ARSA c.465+1G>A Novallele Genotyping Assay identifies a single nucleotide change associated with mutations in the inherited ARSA gene, which is linked with two common alleles, allele I and allele A. These mutations result in diminished activity of arylsulfatase A, causing accumulation of sulfides in cells. These cells are linked to metachromatic leukodystrophy (fat accumulation), which is characterized by neurological disorders like peripheral neuropathy, seizures, and paralysis.


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Product Description

The ARSA c.465+1G>A Novallele Genotyping Assay is used to amplify and identify specific genetic polymorphisms or mutations. This assay provides scientists with a simple way to quickly genotype this locus from isolated human genomic DNA. The assay contains functionally-verified oligonucleotide primers necessary for PCR and subsequent allele identification by DNA melting. For Research Use Only. Not for use in diagnostic procedures.